aco1arm                 A function to estimate parameters in augmented
                        case-only designs, the genotype is ascertained
                        for a random subcohort from the active
                        treatment arm or the placebo arm.
aco2arm                 A function to estimate parameters in Cox
                        proportional hazards model using augmented
                        case-only designs, the genotype is ascertained
                        for a random subcohort from both the active
                        treatment arm and the placebo arm (case-cohort
                        sampling) or a case-control sample in both
                        arms.
acoarm                  A function to estimate parameters in Cox
                        proportional hazard models by augmented
                        case-only designs for randomized clinical
                        trials with failure time endpoints.
acodata                 A dataset from the STEP trial to study the
                        interactions between gene and vaccine on HIV
                        infection
caseonly                A function to deal with case-only designs
char2num                A function used in acoarm to transform
                        categorical variable to integers
mele                    function to compute the maximum estimated
                        likelihood estimator
remove_missingdata      A function used in acoarm to remove missing
                        data
remove_rarevariants     A function used in spmle and acoarm to remove
                        rare-variant covariates
spmle                   function to compute the semiparametric maximum
                        likelihood estimator
whiBioMarker            An example dataset to demostrate the usage of
                        MELE and SPMLE
